DYSKINESIA MANAGEMENT

Paroxysmal Non-Kinesiogenic Dyskinesia

• Clonazepam

Paroxysmal Exertion Induced Dyskinesia

• Tegretol

Paroxysmal Hypnogogic Dyskinesia

• Tegretol

Paroxysmal Kinesiogenic Dyskinesia

• Tegretol
• Dilantin
• Acetazolamide (may be combined with tegretol)

Tardive Dyskinesia

Do not use trihexyphenidyl

Use GABA agonists:

• Clonazepam
• Keppra
• Gabapentin

Dopaminergic agents

• Amantadine

Alpha agonists

• Clonidine  

0.1 mg po bid starting dose, OR 0.1 mg a day transdermal weekly patch

Remember to taper, danger of rebound hypertension when stopping.

Slowly taper off the offending neuroleptic if possible

Taper off any Anticholinergics

Neuroprotective agents such as Vitamin E may be added.

If all else fails: DBS to globus pallidus interna